The report came shortly after local sources reported explosions in Isfahan in central Iran.
Flight trackers showed several flights headed for Iran had turned around and diverted from their planned routes, including several Emirati flights.
Israeli missiles have hit a site in Iran, ABC News reported late on Thursday, citing a U.S. official, while Iranian state media reported an explosion in the center of the country, days after Iran launched a retaliatory drone strike on Israel.
Iran’s Fars news agency said an explosion was heard at an airport in the central city of Isfahan but the cause was not immediately known. Iran suspended flights over the cities of Isfahan, Shiraz and Tehran, state media reported.
Several Iranian nuclear sites are located in Isfahan province, including Natanz, centerpiece of Iran’s uranium enrichment program.
Tehran’s Imam Khomeini International Airport was closed to all flights until 0700 GMT, according to a notice to airmen posted on a U.S. Federal Aviation Administration database.
Some Emirates and Flydubai flights that were flying over Iran early on Friday made sudden sharp turns away from the airspace, according to flight paths shown on tracking website Flightradar24.
Analysts and observers have been raising concerns about the risks of the Israel-Gaza war spreading into the rest of the region.
Iran told the United Nations Security Council on Thursday that Israel “must be compelled to stop any further military adventurism against our interests” as the U.N. secretary-general warned that the Middle East was in a “moment of maximum peril.”
Oil prices and jumped on the reports of the Israeli strike. Brent crude futures rose 2% to $88.86 a barrel, the dollar gained broadly, gold rose 1% and S&P 500 futures dropped 1%.
